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Smoking is widespread, with various adverse health consequences, including cancer, heart disease, and respiratory problems

In particular, those who already have airway reactivity (sufferers of asthma, bronchiectasis and COPD) may have increased bronchospasm and poorer control of their disease in the setting of e-cigarette use, due to irritant effects of multiple chemicals found within e-cigarette aerosols, including flavourings (Kosmider et al

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